Positioning proteasomes
نویسندگان
چکیده
منابع مشابه
3 Proteasomes
The major enzyme system catalysing the degradation of intracellular proteins is the proteasome system. A central inner chamber of the cylinder-shaped 20 S proteasome contains the active site, formed by N-terminal threonine residues. The 20 S proteasomes are extremely inefficient in degrading folded protein substrates and therefore one or two multisubunit 19 S regulatory particles bind to one or...
متن کاملProteasomes: multicatalytic proteinase complexes.
The multicatalytic proteinase complex (proteasome) is a highmolecular-mass (approximately 700 kDa) intracellular proteinase which has been isolated under a variety of different names from a wide variety of eukaryotic cells and tissues (reviewed, Rivett, 1989a; Orlowski, 1990). The proteinase complex is composed of at least 24 subunits which include many different polypeptides arranged in a cyli...
متن کاملIntracellular localization of proteasomes.
Proteasomes are present in the cytoplasm and in the nuclei of all eukaryotic cells, however their relative abundance within those compartments is highly variable. In the cytoplasm, proteasomes associate with the centrosomes, cytoskeletal networks and the outer surface of the endoplasmic reticulum (ER). In the nucleus, proteasomes are present throughout the nucleoplasm but are void from the nucl...
متن کاملNuclear Import of Yeast Proteasomes
Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear. During quiescence and cell cycle arrest, proteasomes accumulate in granules in close proximity to the nuclear envelope/ER. With prolonged quiescence in yeast, these proteasome granules ...
متن کاملProteasomes: Machines for All Reasons
Emerging data reveal that besides degrading proteins tagged with ubiquitin, the proteasome plays a more varied and decisive role in cellular regulation than previously imagined. In this issue, Hanna et al. (2007) expand our view of the proteasome by showing that under certain conditions, proteasome composition can be altered to control ubiquitin homeostasis.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1743rr1